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wlosy

By dochodziło do wzrostu włosa, komórki macierzyste mieszków włosowych muszą być stymulowane przez preadipocyty tkanki podskórnej. Odkrycie to może być przełomem w leczeniu łysienia.

Gdybyśmy mogli nakłonić komórki tłuszczowe skóry do komunikowania się z uśpionymi komórkami macierzystymi u podstawy mieszków włosowych, bylibyśmy w stanie doprowadzić do ponownego wzrostu włosa – tłumaczy prof. Valerie Horsley z Uniwersytetu Yale.

Jak wyjaśniają Amerykanie, panowie z łysieniem androgenowym nadal mają komórki macierzyste w tkwiącym w mieszku korzeniu włosa, ale komórki te straciły, niestety, zdolność zapoczątkowywania regeneracji włosa. Naukowcy wiedzieli, że do regeneracji potrzebny jest sygnał ze skóry, jego źródło pozostawało jednak nieznane.

Zespół Horsley zauważył, że gdy włos obumiera, warstwa tłuszczu w tkance podskórnej ulega zmniejszeniu. Z drugiej strony gdy rozpoczyna się wzrost włosa, ta sama warstwa powiększa się w wyniku adipogenezy. Amerykanie ustalili, że do regeneracji włosów u myszy konieczne jest działanie prekursorowych preadipocytów. Okazało się, że produkują one konieczny do wydłużania włosa płytkowy czynnik wzrostu (PDGF, ang. platelet derived growth factors).

Obecnie ekipa z Yale próbuje zidentyfikować inne regulujące wzrost włosa związki wytwarzane przez preadipocyty. Naukowcy chcą też sprawdzić, czy u człowieka sygnalizacja w skórze/mieszkach włosowych odbywa się tak samo jak u myszy.

Źródło: kopalniawiedzy.pl

Komentarzy: 165 w artykule: ”Włos odrasta, bo jedne komórki macierzyste stymulują drugie”

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